Acquisition of antibody to cell surface antigen and method for identification of the antigen

細胞表面抗原に対する抗体取得とその抗原同定

Abstract

【課題】細胞表面抗原に結合する抗体のスクリーニング方法の提供。 【解決手段】本発明は、以下の特徴を有する細胞表面抗原に結合する抗体のスクリーニング方法を提供した。 抗原抗体複合体の低極性溶媒中での洗浄 既に取得済みの抗体(またはそれが結合する抗原)の存在下での抗原抗体反応 更に本発明は、抗体のスクリーニングに有用な、細胞表面抗原の可溶性分画の製造方法を提供する。本発明によって得られた可溶性分画は、抗体が認識する細胞表面抗原の単離にも有用である。 【選択図】なし
<P>PROBLEM TO BE SOLVED: To provide a method for screening an antibody bonding to cell surface antigen. <P>SOLUTION: The invention relates to the method for screening antibody bonding to cell surface antigen comprising following characteristics. An antibody-antigen complex is cleaned in a solvent with extremely low polarity, and the antibody-antigen reaction in the presence of an already acquired antibody (or an antigen connecting to it), and relates to the method comprising production of a soluble fragment of the cell surface antigen which is useful for screening the antibody. The soluble fragment obtained by the invention is useful for isolation of cell surface antigen which is recognized by the antibody. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Claims

Description

Topics

Download Full PDF Version (Non-Commercial Use)

Patent Citations (3)

    Publication numberPublication dateAssigneeTitle
    WO-0220722-A2March 14, 2002Board Of Regents, The University Of Texas SysteProcedes et compositions utilises pour le ciblage in vitro
    WO-0220723-A2March 14, 2002Board Of Regents, The University Of Texas SystemCompositions et procédés se rapporant à des peptides ciblants chez l'homme in vivo
    WO-0220822-A2March 14, 2002Board Of Regents, The University Of Texas SystemBiopanning et analyse rapide de ligands interactifs selectifs (brasil)

NO-Patent Citations (0)

    Title

Cited By (52)

    Publication numberPublication dateAssigneeTitle
    US-9585956-B2March 07, 2017Ac Immune S.A., Genentech, Inc.Polynucleotides encoding anti-amyloid beta monoclonal antibodies
    WO-2017176055-A1October 12, 2017경희대학교산학협력단Microbilles pour la culture cellulaire et procédé de suivi de culture cellulaire utilisant ces dernières
    CN-102282256-BSeptember 17, 2014凯奥目生物科学株式会社Method for producing antibody directed against protein expressed on cell surface
    US-9540432-B2January 10, 2017AbbVie Deutschland GmbH & Co. KG, Abbvie Inc.Anti-Aβ globulomer 7C6 antibodies
    US-9598496-B2March 21, 2017Perseus Proteomics Inc., University Of MiyazakiAntibody capable of specifically recognizing transferrin receptor
    JP-2008278792-ANovember 20, 2008Mitsubishi Rayon Co Ltd, 三菱レイヨン株式会社タンパク質含有溶液の製造方法
    US-8895004-B2November 25, 2014AbbVie Deutschland GmbH & Co. KGMethod for the treatment of amyloidoses
    US-8246954-B2August 21, 2012Ac Immune S.A., Genentech, Inc.Methods of treating amyloidosis with humanized anti-beta-amyloid antibodies
    US-8124353-B2February 28, 2012Ac Immune S.A., Genentech, Inc.Methods of treating and monitoring disease with antibodies
    US-9221900-B2December 29, 2015Ac Immune S.A., Genentech, Inc.Methods for identifying safe and functional humanized antibodies
    US-9822171-B2November 21, 2017AbbVie Deutschland GmbH & Co. KG, Abbvie Inc.Amyloid-beta binding proteins
    US-8987419-B2March 24, 2015AbbVie Deutschland GmbH & Co. KG, Abbvie Inc.Amyloid-beta binding proteins
    US-9388249-B2July 12, 2016Amano Enzyme Inc.Method of classifying antibody, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same
    WO-2015034052-A1March 12, 2015国立大学法人 宮崎大学, 学校法人藤田学園, 株式会社ペルセウスプロテオミクスAnticorps qui réagit spécifiquement avec l'intégrine humaine a6b4
    US-8613923-B2December 24, 2013Ac Immune S.A., Genentech, Inc.Monoclonal antibody
    WO-2008156621-A1December 24, 2008Ac Immune S.A., Genentech, Inc.Monoclonal anti beta amyloid antibody
    US-7901942-B2March 08, 2011Tohoku UniversityMethod of quantifying membrane protein by mass spectrometry using peptide selection criteria
    US-9176150-B2November 03, 2015AbbVie Deutschland GmbH & Co. KGAmyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
    US-8877190-B2November 04, 2014Abbvie Inc., AbbVie Deutschland GmbH & Co. KGAβ conformer selective anti-Aβ globulomer monoclonal antibodies
    US-9403902-B2August 02, 2016Ac Immune S.A., Genentech, Inc.Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody
    US-9273140-B2March 01, 2016Fujita Health University, Perseus Proteomics Inc.Antibody for detecting DNA damage in cells utilizing cell membrane surface antigen Ly6D
    US-9593165-B2March 14, 2017University Of Miyazaki, Perseus Proteomics Inc.Antibody capable of specifically recognizing transferrin receptor
    WO-2014073641-A1May 15, 2014国立大学法人 宮崎大学, 株式会社ペルセウスプロテオミクスAnticorps capable de reconnaître spécifiquement un récepteur de transferrine
    US-9090672-B2July 28, 2015Chiome Bioscience Inc.Method for producing antibody directed against protein expressed on cell surface
    EP-2975057-A1January 20, 2016Fujita Health UniversityNovel anti-cd73 antibody
    WO-2008007648-A1January 17, 2008Institute For Antibodies Co., Ltd.Method of classifying antigen, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same
    WO-2012153707-A1November 15, 2012株式会社ペルセウスプロテオミクス, 国立大学法人 宮崎大学Antibody specifically recognising transferrin receptor
    JP-2017012181-AJanuary 19, 2017学校法人藤田学園, Fujita GakuenAntibody and application thereof
    US-8188249-B2May 29, 2012Amgen Fremont Inc., Warner-Lambert Company LlcNucleic acid molecules encoding antibodies to M-CSF
    JP-WO2007055283-A1April 30, 2009Jsr株式会社, Jsr株式会社, 国立大学法人 東京大学, 国立大学法人 東京大学, 株式会社ペルセウスプロテオミクス核内受容体タンパク質複合体のプロテオミクス解析方法
    WO-2007055116-A1May 18, 2007Tohoku University質量分析計を使った膜タンパク質の定量方法
    WO-2010064454-A1June 10, 2010株式会社カイオム・バイオサイエンスMethod for producing antibody directed against protein expressed on cell surface
    US-9718883-B2August 01, 2017Amgen Fremont Inc., Warner-Lambert Company LlcAntibodies to M-CSF
    US-9175094-B2November 03, 2015Ac Immune S.A., Genentech, Inc.Monoclonal antibody
    US-7892544-B2February 22, 2011Ac Immune Sa, Genentech, Inc.Humanized anti-beta-amyloid antibody
    JP-2015143226-AAugust 06, 2015学校法人藤田学園, Fujita GakuenAntibody and application thereof
    US-9146244-B2September 29, 2015Ac Immune S.A.Polynucleotides encoding an anti-beta-amyloid monoclonal antibody
    JP-5696316-B2April 08, 2015株式会社カイオム・バイオサイエンス細胞表面に発現したタンパク質に対する抗体作製法
    JP-2008278794-ANovember 20, 2008Mitsubishi Rayon Co Ltd, 三菱レイヨン株式会社生細胞を含有しないタンパク質含有溶液の製造方法
    JP-2013194043-ASeptember 30, 2013Univ Of Miyazaki, 国立大学法人 宮崎大学, Perseus Proteomics Inc, 株式会社ペルセウスプロテオミクストランスフェリン受容体抗体
    JP-2012511033-AMay 17, 2012テゴファーム コーポレーション多価化合物の可逆阻害用マスキングリガンド
    US-7772375-B2August 10, 2010Ac Immune S.A.Monoclonal antibodies that recognize epitopes of amyloid-beta
    EP-2527366-A1November 28, 2012AC Immune S.A., Genentech, Inc.Monoclonal anti beta amyloid antibody
    JP-WO2014073641-A1September 08, 2016国立大学法人 宮崎大学, 国立大学法人 宮崎大学, 株式会社ペルセウスプロテオミクストランスフェリン受容体を特異的に認識できる抗体
    WO-2008059959-A1May 22, 2008The Research Foundation For Microbial Diseases Of Osaka UniversityAgent promoteur de l'étirement des nerfs et agent inhibiteur de l'étirement des nerfs
    JP-4670060-B2April 13, 2011国立大学法人東北大学質量分析計を使った膜タンパク質の定量方法
    WO-2006106976-A1October 12, 2006Osaka University, Tottori University, Biomedics Inc.細胞膜表面抗原に対する抗体のアッセイ法
    US-9359430-B2June 07, 2016Abbvie Inc., AbbVie Deutschland GmbH & Co. KGAbeta conformer selective anti-Abeta globulomer monoclonal antibodies
    US-8048420-B2November 01, 2011Ac Immune S.A., Genentech, Inc.Monoclonal antibody
    JP-2014528081-AOctober 23, 2014エクスプレッション、パソロジー、インコーポレイテッドExpression Pathology, Inc., エクスプレッション、パソロジー、インコーポレイテッドExpression Pathology, Inc.死受容体5タンパク質に対するmrm/srmアッセイ
    US-9062101-B2June 23, 2015AbbVie Deutschland GmbH & Co. KG, Abbvie Inc.Amyloid-beta binding proteins
    JP-5980202-B2August 31, 2016株式会社ペルセウスプロテオミクス, 国立大学法人 宮崎大学, 国立大学法人 宮崎大学トランスフェリン受容体を特異的に認識できる抗体